Active Absorption of Minerals in GIT

 Active Absorption of Minerals in GIT

Calcium ions are actively absorbed into the blood, especially from the duodenum, and the amount of calcium ion absorption is exactly controlled to supply the daily need of the body for calcium. One important factor controlling calcium absorption is parathyroid hormone secreted by the parathyroid glands, and another is vitamin D. Parathyroid hormone activates vitamin D, and the activated vitamin D in turn greatly enhances calcium absorption.

Iron ions are also actively absorbed from the small intestine. Iron, Potassium, magnesium, phosphate, and probably still other ions can also be actively absorbed through the intestinal mucosa. In general, the monovalent ions are absorbed with ease and in great quantities.

Conversely, bivalent ions are normally absorbed in only small amounts; for example, maximum absorption of calcium ions is only 1/50 as great as the normal absorption of sodium ions. Only small quantities of the bivalent ions are normally required daily by the body.

Absorption of Carbohydrates

Essentially all the carbohydrates in the food are absorbed in the form of monosaccharides; only a small fraction is absorbed as disaccharides and almost none as larger carbohydrate compounds. The most abundant of the absorbed monosaccharides is glucose, usually accounting for more than 80 percent of carbohydrate calories absorbed. The reason for this is that glucose is the final digestion product of our most abundant carbohydrate food, the starches. The remaining 20 percent of absorbed monosaccharides is composed almost entirely of galactose and fructose, the galactose derived from milk and the fructose as one of the monosaccharides digested from cane sugar. All the monosaccharides are absorbed by an active transport process.

Glucose is transported by a Glucose Sodium Co-Transport Mechanism. In the absence of sodium transport through the intestinal membrane, virtually no glucose can be absorbed. The reason is that glucose absorption occurs in a co-transport mode with active transport of sodium.

Stages in the transport of sodium through the intestinal membrane

1. First stage is active transport of sodium ions through the basolateral membranes of the intestinal epithelial cells into the blood, thereby depleting sodium inside the epithelial cells.

2. Second stage decrease of sodium inside the cells causes sodium from the intestinal lumen to move through the brush border of the epithelial cells to the cell interiors by a process of secondary active transport. That is, a sodium ion combines with a transport protein, but the transport protein will not transport the sodium to the interior of the cell until the protein also combines with some other appropriate substance such as glucose.

Intestinal glucose also combines simultaneously with the same transport protein and then both the sodium ion and glucose molecule are transported together to the interior of the cell. Thus, the low concentration of sodium inside the cell literally drags sodium to the interior of the cell and along with it the glucose at the same time.

Once inside the epithelial cell, other transport proteins and enzymes cause facilitated diffusion of the glucose through the cell’s basolateral membrane into the para cellular space and from there into the blood. To summarize, it is the initial active transport of sodium through the basolateral membranes of the intestinal epithelial cells that provides the eventual motive force for moving glucose also through the membranes.